AVL-292
AVL-292 Basic information
- Product Name:
- AVL-292
- Synonyms:
-
- AVL-292
- LMK-435
- N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide
- 2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
- CC-292 (AVL-292)
- CC-292,LMK-435
- N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292
- CC-292
- CAS:
- 1202757-89-8
- MF:
- C22H22FN5O3
- MW:
- 423.44
- Product Categories:
-
- Inhibitors
- Mol File:
- 1202757-89-8.mol
AVL-292 Chemical Properties
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- 13.22±0.70(Predicted)
- color
- White to khaki
- CAS DataBase Reference
- 1202757-89-8
AVL-292 Usage And Synthesis
Uses
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]
target
Btk
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