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CNX-774

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CNX-774 Basic information

Product Name:
CNX-774
Synonyms:
  • CNX-774
  • 4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
  • 4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
  • 4-[4-[[5-Fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide CNX-774
  • 4-(4-((4-((3-Acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamid
  • 2-Pyridinecarboxamide, 4-[4-[[5-fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-
  • 4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
  • CNX774; CNX 774
CAS:
1202759-32-7
MF:
C26H22FN7O3
MW:
499.5
Product Categories:
  • Inhibitors
  • API
Mol File:
1202759-32-7.mol
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CNX-774 Chemical Properties

Density 
1.383±0.06 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
Soluble in DMSO
form 
Powder
pka
13.22±0.70(Predicted)
color 
Light yellow to yellow
CAS DataBase Reference
1202759-32-7
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CNX-774 Usage And Synthesis

Uses

CNX-774 is an irreversible, orally active, and highly selective inhibitor of Bruton’s tyrosine kinase (BTK) and can be used for the treatment of rheumatoid arthritis (RA).

Biological Activity

cnx-774 is an orally active and selective inhibitor of btk with ic50 value of <1 nm.bruton’s tyrosine kinase (btk) is an important enzyme in the b-cell antigen receptor (bcr) signaling pathway and also plays an important role in mast cell activation and b cell maturation.cnx-774 is an orally active, irreversible and selective btk inhibitor with ic50 value of <1 nm. cnx-774 formed covalent bond with the cys481 residue within the atp binding site of btk. in cellular assays, cnx-774 inhibited btk with ic50 values of 1-10 nm [1].

References

[1]. akinleye a, chen y, mukhi n, et al. ibrutinib and novel btk inhibitors in clinical development. j hematol oncol, 2013, 6: 59.

CNX-774Supplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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info@chemexpress.com
MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
AdooQ BioScience, LLC
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+1 (866) 930-6790
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info@adooq.com
Shanghai YuLue Chemical Co., Ltd.
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021-60345187 13671753212
Email
lzz841106@aliyun.com
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CNX-774(1202759-32-7)Related Product Information