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Icariside I hydrate

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Icariside I hydrate Basic information

Product Name:
Icariside I hydrate
Synonyms:
  • Icariside I hydrate
  • Maohuoside A
  • Pletypetaloside
  • 4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-3,5-dihydroxy-8-(3-hydroxy-3-methylbutyl)-2-(4-methoxyphenyl)-
  • 3,5-Dihydroxy-8-(3-hydroxy-3-methylbutyl)-2-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
  • orally,MAPK,osteogenesis,Maohuoside A,inhibit,Transforming growth factor beta receptors,natural,TGF-β Receptor,herb,Inhibitor,BMP
  • Maohuoside A, 10 mM in DMSO
CAS:
128988-55-6
MF:
C27H32O12
MW:
548.54
Mol File:
128988-55-6.mol
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Icariside I hydrate Chemical Properties

Melting point:
222-224℃
Boiling point:
838.2±65.0 °C(Predicted)
Density 
1.508±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
Solid
pka
6.16±0.40(Predicted)
color 
Light yellow to green yellow
InChIKey
KKZRHUJZVYWXFJ-DUZPRZLHNA-N
SMILES
C(C1C(=CC(O)=C2C(C(O)=C(C3C=CC(OC)=CC=3)OC=12)=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)CC(O)(C)C |&1:23,24,25,27,29,r|
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Icariside I hydrate Usage And Synthesis

Uses

Maohuoside A, a single compound isolated from the E. koreanum that potently promotes osteogenesis. Maohuoside A enhances the osteogenesis of bone marrow-derived mesenchymal stem cells via bone morphogenetic protein (BMP) and MAPK signaling pathways[1][2].

References

[1] Ming Cai, et al. Maohuoside A Acts in a BMP-dependent Manner During Osteogenesis. Phytother Res. 2013 Aug;27(8):1179-84. DOI:10.1002/ptr.4840
[2] Lei Yang, et al. Maohuoside A Promotes Osteogenesis of Rat Mesenchymal Stem Cells via BMP and MAPK Signaling Pathways. Mol Cell Biochem. 2011 Dec;358(1-2):37-44. DOI:10.1007/s11010-011-0918-y

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