Mutant IDH1 inhibitor
Mutant IDH1 inhibitor Basic information
- Product Name:
- Mutant IDH1 inhibitor
- Synonyms:
-
- Mutant IDH1 inhibitor
- (4S)-3-[2-[[(1S)-1-[4-[(4-Acetyl-1-piperazinyl)methyl]phenyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-2-oxazolidinone
- SCHEMBL14831541
- 2-Oxazolidinone, 3-[2-[[(1S)-1-[4-[(4-acetyl-1-piperazinyl)methyl]phenyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)-
- Mutant IDH1 inhibitor,Mutant IDH-1 inhibitor,inhibit,Isocitrate Dehydrogenase (IDH),Inhibitor
- CAS:
- 1429180-08-4
- MF:
- C25H34N6O3
- MW:
- 466.58
- Mol File:
- 1429180-08-4.mol
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Mutant IDH1 inhibitor Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 34 mg/mL (72.87 mM)
- form
- Powder
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Mutant IDH1 inhibitor Usage And Synthesis
Description
Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.
in vitro
In Vitro:Mutant IDH1 inhibitor is a potent IDH1 R132H inhibitor, and used for the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer[1].
References
References:[1]. 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation. Patent WO 2013046136 A1 20130404
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