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Sulfacetamide sodium

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Sulfacetamide sodium Basic information

Product Name:
Sulfacetamide sodium
Synonyms:
  • SULFACETAMIDE SODIUM MONOHYDRATE
  • SULFACETAMIDE SODIUM SALT HYDRATE
  • SODIUM SULFACETAMIDE HYDRATE
  • N-SULFANILYLACETAMIDE MONOSODIUM SALT, MONOHYDRATE
  • N1-ACETYLSULFANILAMIDE MONOSODIUM SALT MONOHYDRATE
  • N1-ACETYLSULFANILAMIDE SODIUM SALT HYDRATE
  • N-(4-AMINOPHENYL-SULFONYL)ACETAMIDE SODIUM SALT HYDRATE
  • BIO-FARMA BF003142
CAS:
6209-17-2
MF:
C8H13N2NaO4S
MW:
256.25
EINECS:
642-939-4
Product Categories:
  • ALBUCID
Mol File:
6209-17-2.mol
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Sulfacetamide sodium Chemical Properties

Melting point:
263-265°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble50mg/mL
form 
powder
color 
white to off-white
Water Solubility 
Freely soluble in water. Insoluble in chloroform, ether, and benzene.
CAS DataBase Reference
6209-17-2
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37
WGK Germany 
3
RTECS 
AC8480000
HS Code 
29350090

MSDS

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Sulfacetamide sodium Usage And Synthesis

Chemical Properties

White or yellowish-white, crystalline powder.

Uses

Sulfacetamide sodium salt hydrate is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. It adapts to cure trachoma, conjunctivitis, keratitis.

Uses

Antibacterial;Inhibitor of folic acid synthesis

Definition

ChEBI: Sulfacetamide sodium is an organic sodium salt that is the monohydrate form of sulfacetamide sodium. It has a role as an antimicrobial agent, an antiinfective agent and an EC 2.5.1.15 (dihydropteroate synthase) inhibitor. It is an organic sodium salt and a hydrate. It contains a member of sulfacetamide sodium anhydrous.

General Description

N-Sulfanilylacetamide monosodium salt (Sodium Sulamyd)is obtained as the monohydrate and is a white, odorless, bitter,crystalline powder that is very soluble (1:2.5) in water.Because the sodium salt is highly soluble at the physiologicalpH of 7.4, it is especially suited, as a solution, forrepeated topical applications in the local management ofophthalmic infections susceptible to sulfonamide therapy.

Biochem/physiol Actions

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

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