H-D-TYR-OME HCL
H-D-TYR-OME HCL Basic information
- Product Name:
- H-D-TYR-OME HCL
- Synonyms:
-
- (R)-Methyl 2-aMino-3-(4-hydroxyphenyl)propanoate hydrochloride
- H-D-Tyr-OMe hydrochloride
- H-D-Tyr-OMe
- D-Tyr-OMe·HCl
- D-Tyrosine methyl ester hydrochloride≥ 98% (HPLC)
- D-TYROSINE ETHYL OME HCl
- Methyl D-Tyrosinate Hydrochloride,99%e.e.
- H-D-TYR-OME HCL
- CAS:
- 3728-20-9
- MF:
- C10H14ClNO3
- MW:
- 231.68
- EINECS:
- 223-084-2
- Product Categories:
-
- Amino Acids and Derivatives
- Amino hydrochloride
- Amino Acid Derivatives
- Mol File:
- 3728-20-9.mol
H-D-TYR-OME HCL Chemical Properties
- Melting point:
- 177-179℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White to off-white
- CAS DataBase Reference
- 3728-20-9(CAS DataBase Reference)
H-D-TYR-OME HCL Usage And Synthesis
Chemical Properties
Crystalline
Uses
D-Tyrosine methyl ester hydrochloride is an intermediate in the synthesis of oxybutynin chloride (O868525), an inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.
Synthesis
67-56-1
556-02-5
3728-20-9
General procedure for the synthesis of methyl (R)-2-amino-3-(4-hydroxyphenyl)propanoate hydrochloride from methanol and D-tyrosine: (2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid (49) (1.07 g, 5.9 mmol) was dissolved in methanol, and the reaction was completed to give methyl (2R)-2-amino-3-(4-hydroxyphenyl)propanoate (50) . The product characterization data were as follows: melting point 176°C (literature values in agreement); 1H NMR (DMSO-d6) δ: 6.82 (d, J = 8.4 Hz, 2H, ArH3' and ArH5'), 4.13 (t, J = 6.9 Hz, 1H, H2), 3.83 (s, 3H, OCH3), 3.22 (dd, J = 6.0, 14.4 Hz. 1H, 3Ha), 3.12 (dd, J = 6.9, 14.7 Hz, 1H, 3Hb). Mass spectrum (chemical ionization, positive ion mode) m/z: 196 (100%) [M+]. High Resolution Mass Spectrometry (HRMS) calculated value of C10H14NO3: 196.0974, measured value: 196.0985.
References
[1] Organic Letters, 2002, vol. 4, # 2, p. 265 - 267
[2] Organic and Biomolecular Chemistry, 2007, vol. 5, # 4, p. 636 - 643
[3] Patent: WO2006/74501, 2006, A1. Location in patent: Page/Page column 152
[4] Tetrahedron, 2008, vol. 64, # 49, p. 11270 - 11290
[5] Organic and Biomolecular Chemistry, 2005, vol. 3, # 7, p. 1233 - 1239
H-D-TYR-OME HCLSupplier
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 400-6106006
- saleschina@alfa-asia.com
- Tel
- +86 351 7031519
- sales@RHFChem.com
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
H-D-TYR-OME HCL(3728-20-9)Related Product Information
- D-TYROSINE ETHYL ESTER HYDROCHLORIDE
- D-Tyrosine
- H-D-TYR-OTBU
- (R)-2-AMino-3-(4-hydroxyphenyl)propanaMide hydrochloride
- D-TYROSINE-OBZL P-TOSYLATE
- H-D-TYR-OME HCL
- H-L-TYR-OME HCL,H-TYR-OME HCL
- H-D-TYR(ALL)-OME HCL
- METHYL (2R)-2-AMINO-3-(2-CHLORO-4-HYDROXYPHENYL)PROPANOATE
- METHYL (2R)-2-AMINO-3-(3-CHLORO-4-METHOXYPHENYL)PROPANOATE
- H-3,5-DIIODO-TYR-OME HCL,H-D-3,5-DIIODO-TYR-OME HCL
- H-DL-TYR-OME HCL
- METHYL (2R)-2-AMINO-3-(3-CHLORO-4-HYDROXYPHENYL)PROPANOATE
- H-D-TYR(TBU)-ALLYL ESTER HCL
- Boc-Tyr-Ome·HCl
- N-ME-TYR-OME HCL
- N-ME-DL-TYR-OME HCL
- H-LEU-LEU-LEU-TYR-OME HCL