10-Nitrocamptothecin Chemical Properties

Boiling point:

827.4±65.0 °C(Predicted)

Density 

1.63±0.1 g/cm3(Predicted)

pka

11.17±0.20(Predicted)

10-Nitrocamptothecin Usage And Synthesis

Uses

Whether cells can divide depends on the two key points of entering S phase and M phase. Studies have found that 10-Nitrocamptothecin can induce apoptosis. After administration, both S phase and G2M phase of cell growth are delayed. Inhibition occurred throughout the cell cycle and was found to be dose- and time-dependent.

Definition

ChEBI: Rubitecan is a pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin. It has a role as an antineoplastic agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and a prodrug. It is a pyranoindolizinoquinoline, a C-nitro compound, a semisynthetic derivative, a tertiary alcohol and a delta-lactone.

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