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PI-3065

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PI-3065 Basic information

Product Name:
PI-3065
Synonyms:
  • PI-3065
  • 6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
  • PI-3065|PI3065
  • 4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine
  • 6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine
  • 6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine PI-3065
  • PI-3065, >=98%
  • 129556
CAS:
955977-50-1
MF:
C27H31FN6OS
MW:
506.64
Product Categories:
  • Inhibitors
Mol File:
955977-50-1.mol
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PI-3065 Chemical Properties

Density 
1.372±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
14.80±0.30(Predicted)
color 
White to off-white
CAS DataBase Reference
955977-50-1
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PI-3065 Usage And Synthesis

Biological Activity

pi-3065 is a small molecule and selective inhibitor of p110δkinase with an ki value of 1.5nm and ic50 value of 5nm [1].pi-3065 has been reported to selectively inhibit p110δkinase with ki values of 15nm, 110nm, 130nm and 940nm, ic50 values of 5nm, 91nm, 600nm and >10000nm for p110δ, p110α, p110β and p110γ, respectively. in addition, pi-3065 has been revealed to inhibit 4t1 tumour growth and metastasis. pi-3065 has also noted to prolong survival and reduce the incidence of macroscopic metastases and other disease-associated pathologies [1].

in vitro

PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.

target

p110α

910 nM (IC 50 )

p110β

600 nM (IC 50 )

p110δ

5 nM (IC 50 )

storage

Store at -20°C

PI-3065Supplier

Shanghai Dongyang Biotechnology Co., Ltd. Gold
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Email
info@hope-chem.com
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PI-3065(955977-50-1)Related Product Information