Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Basic information
- Product Name:
- Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
- Synonyms:
-
- Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
- Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride
- Mn(III)TBAP (chloride)
- 5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP)
- 5,10,15,20-Tetrakis(4-carboxyphenyl)-21H,23H-porphine]manganese(III) chloride
- MnTBAP chloride, Superoxide dismutase (SOD) mimetic
- MnTBAP chloride, 10 mM in DMSO
- CAS:
- 55266-18-7
- MF:
- C48H28ClMnN4O8
- MW:
- 879.148969
- Mol File:
- 55266-18-7.mol
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Chemical Properties
- storage temp.
- -20C
- solubility
- Soluble in 0.1M NaOH
- form
- Brown solid
- color
- Black
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month.
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride Usage And Synthesis
Description
MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide.
Uses
MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger.
General Description
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Biochem/physiol Actions
Cell permeable: yes
in vivo
MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].
| Animal Model: | C57BL/6J mice with 5/6 nephrectomy (Nx)[1] |
| Dosage: | 10?mg/kg |
| Administration: | IP; three times per week for twelve weeks |
| Result: | Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys. |
IC 50
NFκB
References
[1] CSABA SZABÓ Andrew L S Brian J Day. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger[J]. FEBS Letters, 1996, 381 1-2: 82-86. DOI:10.1016/0014-5793(96)00087-7
[2] K M FAULKNER I F S I Liochev. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.[J]. The Journal of Biological Chemistry, 1994, 269 38: 23471-23476.
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