Basic information Safety Supplier Related

Sofosbuvir IMpurity B

Basic information Safety Supplier Related

Sofosbuvir IMpurity B Basic information

Product Name:
Sofosbuvir IMpurity B
Synonyms:
  • Sofosbuvir IMpurity B
  • (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
  • Sofosbuvir impurity K
  • (2S)-isopropyl 2-(((((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
  • sofosbuvir impurity Y008005-K
  • Sofosbuvir Chloro Analog
  • L-Alanine, N-[[P(S),2'R]-2'-chloro-2'-deoxy-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester
  • Sofosbuvir Chloro Analogue
CAS:
1496552-51-2
MF:
C22H29ClN3O9P
MW:
545.91
Mol File:
1496552-51-2.mol
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Sofosbuvir IMpurity B Chemical Properties

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
9.39±0.10(Predicted)
color 
Light yellow to yellow
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Sofosbuvir IMpurity B Usage And Synthesis

Uses

Chloro Sofosbuvir is an impurity of Sofosbuvir (P839640); a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Sofosbuvir IMpurity BSupplier

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