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ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Pharmaceutical Impurity Reference Standards >  (alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile

(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile

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(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Basic information

Product Name:
(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile
Synonyms:
  • (alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile
  • Entacapone impurity H
  • Entacapone Impurity 24(Entacapone EP Impurity H)
  • (E)-3-(3,4-dihydroxy-5-nitrophenyl)-2-(piperidine-1-carbonyl)prop-2-enenitrile
  • Entacapone Impurity 8(Entacapone EP Impurity H)
  • (2E)-3-(3,4-Dihydroxy-5-nitrophenyl
  • 1-Piperidinepropanenitrile, α-[(3,4-dihydroxy-5-nitrophenyl)methylene]-β-oxo-, (αE)-
  • -[(3,4-Dihydroxy-5-nitrophenyl)methylene]-&beta
CAS:
1150310-15-8
MF:
C15H15N3O5
MW:
317.3
Mol File:
1150310-15-8.mol
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(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Chemical Properties

Melting point:
207-208℃ (ethanol )
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(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Usage And Synthesis

Uses

(αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.

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