[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Basic information
- Product Name:
- [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
- Synonyms:
-
- [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
- (R)-3-AMino-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)
- W146
- (R)-3-AMINO-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W146
- W146 TFA
- CAS:
- 909725-62-8
- MF:
- C18H28F3N2O6P
- MW:
- 456.3936906
- Mol File:
- 909725-62-8.mol
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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Methanol: 0.1 mg/ml
- form
- A crystalline solid
- color
- White to off-white
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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Usage And Synthesis
Uses
W146 is a selective antagonists of spingosine-1-phosphate receptor subtype 1.
Biological Activity
W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
in vivo
W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone[3]
The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice[3].
| Animal Model: | Mice (4-6-week-old)[3] . |
| Dosage: | 5 mg/kg. |
| Administration: | IP, 1 hour prior to AMD3100 (ADM) administration. |
| Result: | Significantly increased in KSL-HSPC mobilization compared to that in mice pretreated with dextran followed by AMD3100 administration. |
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)Supplier
EMMX Biotechnology LLC
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- 400-9205774
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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)(909725-62-8)Related Product Information
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