MPEG11-CH2CH2COONHS Chemical Properties

Boiling point:

684.3±65.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

storage temp. 

-20°C, protect from light, stored under nitrogen

form 

Liquid

color 

Colorless to light yellow

InChIKey

ZMXRHHJWXLKMTL-UHFFFAOYSA-N

SMILES

C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC

MPEG11-CH2CH2COONHS Usage And Synthesis

Uses

m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Biological Activity

m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs; Alkyl/ether

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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