SCIADOPITYSIN Chemical Properties

Melting point:

296-298°C

Boiling point:

839.6±65.0 °C(Predicted)

Density 

1.445±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in ethanol and methan

form 

powder

pka

6.16±0.40(Predicted)

color 

Light yellow

LogP

5.500 (est)

CAS DataBase Reference

521-34-6

Safety Information

Safety Statements 

24/25

HS Code 

29329990

SCIADOPITYSIN Usage And Synthesis

Description

Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC₅₀ = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC₅₀ = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.

Definition

ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.

target

ROS | MMP(e.g.TIMP) | NO | TNF-α | ATPase | cAMP | Beta Amyloid

SCIADOPITYSIN(521-34-6)Related Product Information

• 4-Phenylphenol
• 3-Biphenylmethanol
• SCIADOPITYSIN
• 2-METHOXYBIPHENYL
• 3,3'-Dimethylbiphenyl
• 4-METHOXY-3-METHYLBENZYL ALCOHOL
• 4'-Hydroxy-3'-methylacetophenone
• 2-Phenylphenol
• 1-(2-Hydroxy-5-methylphenyl)ethanone
• 2,4-Dihydroxy-3-methylbenzaldehyde
• 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE
• 2,2'-DIMETHOXYBIPHENYL
• 4',7-DIMETHOXY-5-HYDROXYFLAVONE
• 2-PROPENAL, 3-(3-METHYLPHENYL)-,(2E)
• BILOBETIN
• 3-Phenylbenzaldehyde
• 4,6-DIMETHOXYSALICYLALDEHYDE
• 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE