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Everolimus Ring-Opening Impurity

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Everolimus Ring-Opening Impurity Basic information

Product Name:
Everolimus Ring-Opening Impurity
Synonyms:
  • EverolimusRetroaldolDegradationProduct
  • (S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)
  • Everolimus Impurity 012-99
  • Everolimus Open-Ring Impurity
  • Everolimus Open-Ring Aldehyde Impurity
  • Everolimus Impurity 33
  • (2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl (S)-1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
  • (S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl 1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
CAS:
1708118-13-1
MF:
C53H83NO14
MW:
958.23
Mol File:
1708118-13-1.mol
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Everolimus Ring-Opening Impurity Chemical Properties

Melting point:
45-50°C
Boiling point:
954.8±75.0 °C(predicted)
Density 
1.15±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
storage temp. 
Amber Vial, -86°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
10.56±0.60(predicted)
color 
White to Off-White
Stability:
Light and temperature Sensitive
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Everolimus Ring-Opening Impurity Usage And Synthesis

Uses

Everolimus Retroaldol Degradation Product is an impurity of Everolimus (E945400). Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Everolimus Impurity D

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