(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-acetamidopropanoic acid Chemical Properties

Melting point:

237 °C (decomp)

Boiling point:

684.9±55.0 °C(Predicted)

Density 

1.307±0.06 g/cm3(Predicted)

storage temp. 

Store at room temperature

pka

3.44±0.10(Predicted)

Appearance

White to off-white Solid

optical activity

Consistent with structure

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-acetamidopropanoic acid Usage And Synthesis

Uses

3-(acetamido)-N-[fluorenylmethoxycarbonyl]-L-alanine is an amino acid derivative mainly used in laboratory biochemical experimental research.

Synthesis

A THF (5 mL) solution of acetic anhydride was added to a cloudy mixture of Fmoc-DAP-H (1) (980 mg, 3.0 mmol) and pyridine (483 ??L, 6.0 mmol) in THF (15 mL) at room temperature and with stirring.After 4 hr, the LCMS showed a clarified, light-yellow solution that was fully reacted. The reaction was evaporated under reduced pressure. The residue was dissolved in EtOAc (150 mL), washed with 0.1 M NaHSO4 (50 mL), water (50 mL), and saturated saline (50 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure to give 1.1 g of white solid crude product. The crude product was purified by preparative HPLC to afford 0.99 g (90% yield) of 3-(acetylamino)-N-[fluorenylmethoxycarbonyl]-L-alanine.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-acetamidopropanoic acid(181952-29-4)Related Product Information

• FMOC-DAP(MTT)-OH
• FMOC-D-DAP(ALOC)-OH
• FMOC-D-DAP(DDE)-OH
• L-DAB HBR
• Fmoc-Dap(Alloc)-OH
• FMOC-D-DAP(IVDDE)-OH
• N-α –Fmoc-N-β-1-(4,4-dimethyl-2,6-dioxocyclohe
• FMOC-D-DAP(BOC)-OH
• DL-2,4-DIAMINOBUTYRIC ACID DIHYDROCHLORIDE
• FMOC-DOPA(ACETONIDE)-OH
• FMOC-D-DAP(MTT)-OH
• Fmoc-D-Dap(Ac)-OH