1-Boc-5-hydroxyindole Chemical Properties

Boiling point:

374.5±34.0 °C(Predicted)

Density 

1.16±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

9.55±0.40(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

434958-85-7(CAS DataBase Reference)

Safety Information

HS Code 

2933998090

1-Boc-5-hydroxyindole Usage And Synthesis

Synthesis

General procedure for the synthesis of N-Boc-5-hydroxyindole from tert-butyl 5-(benzyloxy)-1H-indole-1-carboxylate: the product of Example 93A (680 mg, 2.103 mmol) was dissolved in ethanol (20 mL) under nitrogen protection, and 10% palladium carbon (68 mg) and ammonium formate (265 mg, 4.205 mmol) were added. After stirring the reaction for 1 h at room temperature, the reaction mixture was filtered through a 0.45 μm PTFE membrane and the catalyst was washed with methanol. The filtrate was concentrated by rotary evaporator and the resulting residue was dissolved in ethyl acetate (50 mL) and washed sequentially with water (2 × 25 mL) and saturated saline (25 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give N-Boc-5-hydroxyindole (475 mg, 96% yield) as a white solid.

References

[1] Patent: WO2007/76034, 2007, A2. Location in patent: Page/Page column 127
[2] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 57

1-Boc-5-hydroxyindole(434958-85-7)Related Product Information

• Indometacin
• Chrysin
• Indole-3-butyric acid
• Indole-3-acetic acid
• tert-Butyl acrylate
• tert-Butyl methacrylate
• TERT-BUTYL PROPIONATE
• 5-Hydroxyindole
• Butylparaben
• tert-Butyl bromoacetate
• tert-Butyl acetoacetate
• 1-BOC-5-METHOXYINDOLE
• 1-Boc-5-aminoindole
• t-butyl chloroformate
• 5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID
• 5-(TERT-BUTYLDIMETHYLSILYLOXY)-1H-INDOLE-2-BORONIC ACID, N-BOC PROTECTED 98
• 1-(TERT-BUTOXYCARBONYL)-5-METHOXY-1H-INDOL-2-YLBORONIC ACID
• 5-METHOXY-3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER