Basic information Safety Supplier Related

3,5-Diiodo-L-thyronine

Basic information Safety Supplier Related

3,5-Diiodo-L-thyronine Basic information

Product Name:
3,5-Diiodo-L-thyronine
Synonyms:
  • 3,5-Diiodi-L-thyronine
  • 3,5-DIIODO-L -THYRONINE 98%
  • 3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine, O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine
  • 3,5-Diiodo-O-(4-hydroxyphenyl)-L-tyrosine
  • L-Diiodothyronine
  • Alanine, 3-[4-(p-hydroxyphenoxy)-3,5-diiodophenyl]-, L-
  • Diiodo-L-thyronine
  • L-3,5-Diiodothyronine
CAS:
1041-01-6
MF:
C15H13I2NO4
MW:
525.08
EINECS:
213-867-7
Product Categories:
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Medicine intermediate
  • Intermediates
  • Labeling and Diagnostics Reagents
Mol File:
1041-01-6.mol
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3,5-Diiodo-L-thyronine Chemical Properties

Melting point:
255-260 °C (dec.)
Boiling point:
559.4±50.0 °C(Predicted)
Density 
2.095±0.06 g/cm3(Predicted)
vapor pressure 
0.011Pa at 45℃
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Acidic Alcohol (Slightly), Aqueous Base (Slightly)
form 
Solid
pka
2.15±0.30(Predicted)
color 
White to Light Brown
Water Solubility 
20.147mg/L at 20℃
BRN 
2707891
Stability:
Hygroscopic
InChIKey
ZHSOTLOTTDYIIK-ZDUSSCGKSA-N
LogP
1.1 at 25℃
CAS DataBase Reference
1041-01-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
8
HS Code 
29225090

MSDS

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3,5-Diiodo-L-thyronine Usage And Synthesis

Chemical Properties

[α] 25 D +25.2° [5 % solution in 1 M HCl:95 % ethanol (1:2)], off-White Solid.

Uses

3,5-Diiodo-L-thyronine is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism.

Definition

ChEBI: (2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid is a phenylalanine derivative.

Flammability and Explosibility

Not classified

Pharmacology

3,5-Diiodo-L-thyronine is a thyroid hormone with a l-thyroxine-like activity.

Purification Methods

Recrystallise it from EtOH. [Chambers et al. J Chem Soc 3424 1949, Beilstein 14 II 226, 14 III 1565, 14 IV 2372.]

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