2-Chlorocinnamic acid Chemical Properties

Melting point:

208-210 °C(lit.)

Boiling point:

260.71°C (rough estimate)

Density 

1.2377 (rough estimate)

refractive index 

1.5426 (estimate)

storage temp. 

Room temperature.

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Water Solubility 

Insoluble in water

form 

powder to crystal

pka

4.23(at 25℃)

color 

White to Almost white

BRN 

1365198

InChIKey

KJRRTHHNKJBVBO-AATRIKPKSA-N

CAS DataBase Reference

3752-25-8(CAS DataBase Reference)

NIST Chemistry Reference

2-Chlorocinnamic acid(3752-25-8)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

36-26-36/37

WGK Germany 

3

RTECS 

GD8450000

Hazard Note 

Irritant

HS Code 

29124990

MSDS

• Language:English Provider:o-Chlorocinnamic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Chlorocinnamic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder. Insoluble in water, soluble in ethanol, ethyl acetate and other organic solvents.

Uses

2-Chlorocinnamic acid is a kind of trans-cinnamate. It is used in organic synthesis.

Biological Functions

2-Chlorocinnamic acid is a cinnamic acid derivative that inhibits the hydroxylation of phenylpropanoids. It has been shown to inhibit the activity of cinnamic acid derivatives and their hydroxylation in cell lines, which is linked to the inhibition of cellulose acetate synthesis. 2-Chlorocinnamic acid also has an inhibitory effect on the chloride ion and water molecule. The chloride ion may be needed for the formation of hydrochloric acid, which is necessary for cellulose acetate hydrolysis, while water molecules are involved in many biochemical reactions. 2-Chlorocinnamic acid affects human cell lines at temperatures between 10°C and 37°C and at regiospecific sites. This oxidative dehalogenation reaction catalyzed by R. rubra was found to be regiospecific for 2-chlorocinnamic acid; the chloride ion was probably removed after the ring fission reaction.

Synthesis

O-chlorocinnamic acid is prepared by reacting o-phthalaldehyde with malonic acid.

2-Chlorocinnamic acid(3752-25-8)Related Product Information

• 4-(Diethylamino)salicylaldehyde
• Diphenolic acid
• Citric acid
• 2-Nitrocinnamic acid
• Ethyl cinnamate
• Pralmorelin
• alpha-Methylcinnamic acid
• Ethyl 4-methylcinnamate
• Methyl cinnamate
• Folic acid
• Glycine
• DL-α-Tocopherol
• Ethyl 2-(Chlorosulfonyl)acetate
• trans-Cinnamic acid
• 5-Chlorovaleric acid
• Cinnamic acid
• Octyl 4-methoxycinnamate
• Ascoric Acid