3,6-Dihydroxy-4,5-dimethylpyridazine Chemical Properties

Melting point:

347-351 °C

Density 

1.160±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

9.08±0.60(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C6H8N2O2/c1-3-4(2)6(10)8-7-5(3)9/h1-2H3,(H,7,9)(H,8,10)

InChIKey

QLFHLLQTPRTMLL-UHFFFAOYSA-N

SMILES

C1(=O)NNC(=O)C(C)=C1C

CAS DataBase Reference

5754-17-6

Safety Information

Hazard Codes 

T

Hazard Note 

Toxic

HS Code 

2933998090

3,6-Dihydroxy-4,5-dimethylpyridazine Usage And Synthesis

Uses

4,5-Dimethylpyridazine-3,6-diol is a useful research chemical.

Uses

3,6-Dihydroxy-4,5-dimethylpyridazine can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).

References

[1] Patent: US2010/41663, 2010, A1. Location in patent: Page/Page column 41
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 707,708
[3] Journal of the American Chemical Society, 1954, vol. 76, p. 4454,4457
[4] Patent: US2011/34451, 2011, A1. Location in patent: Page/Page column 57
[5] Patent: US2011/34452, 2011, A1. Location in patent: Page/Page column 36

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