N-(3-Trifluoromethylphenyl)piperazine Chemical Properties

Boiling point:

100-102°C 0,1mm

Density 

1.226 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.521(lit.)

Flash point:

>230 °F

storage temp. 

-20°C

pka

8.88±0.10(Predicted)

Sensitive 

Air Sensitive

BRN 

614217

CAS DataBase Reference

15532-75-9(CAS DataBase Reference)

NIST Chemistry Reference

Piperazine, 1-[3-(trifluoromethyl)phenyl]-(15532-75-9)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

2735

WGK Germany 

3

RTECS 

TM2820000

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

29335995

MSDS

• Language:English Provider:3-(1-Piperazino)benzotrifluoride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-(3-Trifluoromethylphenyl)piperazine Usage And Synthesis

Chemical Properties

clear colourless to yellow slightly viscous liquid

Uses

1-[3-(Trifluoromethyl)phenyl]piperazine is used in preparation of (Piperazinylethyl)cyclohexanamide derivatives and used as treatment or prevention of D3 and/or 5HT-2 receptor diseases.

Definition

ChEBI: A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 319, 1996 DOI: 10.1016/0040-4039(95)02162-0

N-(3-Trifluoromethylphenyl)piperazine(15532-75-9)Related Product Information

• Lithium trifluoromethanesulfonate
• Benzotrifluoride
• Trifluoromethanesulfonic acid
• Diphenyl ether
• Dichloromethylphenylsilane
• Methyltriphenylphosphonium bromide
• 1-Methylpiperazine
• (Trifluoromethyl)trimethylsilane
• 1,2-Dimethylhydrazine Dihydrochloride
• Piperazine
• 4-Aminobenzotrifluoride
• 1-BENZHYDRYLPIPERAZINE
• PHENYL VALERATE
• PHENYL RESIN
• 1-(4-CHLORO-3-TRIFLUOROMETHYLPHENYL)PIPERAZINE
• 1-(3-Trifluoromethylphenyl)piperazine hydrochloride
• N-(3-Trifluoromethylphenyl)piperazine
• 1-(4-TRIFLUOROMETHYLPHENYL)PIPERAZINE