Tiamulin fumarate Chemical Properties

Melting point:

147-148°C

Boiling point:

563℃

Flash point:

>110°(230°F)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)

form 

Solid

color 

White

Water Solubility 

Soluble in water

Merck 

13,9495

InChI

InChI=1/C28H47NO4S.C4H4O4/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28;5-3(6)1-2-4(7)8/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t19-,20+,22-,24+,25+,26-,27?,28?;/s3

InChIKey

YXQXDXAHCSEVSD-IHAONTCTSA-N

SMILES

C(/C(=O)O)=C\C(=O)O.C[C@H]1[C@@H]([C@](C[C@@H](OC(=O)CSCCN(CC)CC)C2([C@H](C)CCC31CCC(=O)[C@]32[H])C)(C)C=C)O |&1:9,10,11,13,27,36,r|

CAS DataBase Reference

55297-96-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

RIDADR 

UN2811 6.1/PG 3

WGK Germany 

3

RTECS 

AG9560000

HS Code 

29419090

Tiamulin fumarate Usage And Synthesis

Chemical Properties

White Solid. soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide.

Uses

Tiamulin fumarate is a semisynthetic pleuromutilin antibiotic that binds to the ribosomal peptidyl transferase centre and inhibits protein synthesis. It is a derivative of Pleuromutilin with Antibacterial that targets Gram-positive bacteria as well as a few mycoplasma species.

Application

Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity. The hemi-fumarate provides a stable salt with improved water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action of inhibiting protein synthesis by binding to domain V of 23S rRNA.

Indications

Tiamulin fumarate is mainly used for Mycoplasma suis pneumonia, Haemophilus parasuis, infectious pleuropneumonia and dysentery caused by Treponema swine, and also for chronic respiratory tract of poultry, Mycoplasma pneumonia, infectious rhinitis, Escherichia coli, duck Infectious serositis.

Health Hazard

Inhalation may irritate (cough, short breathing, difficulty in breathing). Headache. It may cause moderate irritation, including a burning sensation, tearing, redness, or swelling. Itching. Causes serious eye irritation. Redness, itching, tears. Stinging. It may cause irritation to the digestive tract. Abdominal pain, nausea.

Mode of action

Tiamulin fumarate is a bacteriostatic antibiotic belonging to the pleuromutilin class, which inhibit protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.

Tiamulin fumarate(55297-96-6)Related Product Information

• Rotundine
• Ketotifen fumarate
• Tiamulin
• Ethylparaben
• CHLOROPHOSPHONAZO III
• Ethyl 2-(Chlorosulfonyl)acetate
• Fumaric acid
• Ethanol
• Dimethyl fumarate
• Ferrous fumarate
• Pleuromulin
• Ethyl acetate
• Telithromycin
• Tulathromycin A
• Tylosin
• Acetic anhydride
• Phenylacetic acid
• ISOOCTYL THIOGLYCOLATE