4-(Hydroxymethyl)phenoxyacetic acid Chemical Properties

Melting point:

112-114 °C

Boiling point:

378.3±22.0 °C(Predicted)

Density 

1.316±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

pka

3.15±0.10(Predicted)

form 

Crystalline Powder

color 

Off-white

biological source

rabbit

BRN 

5260336

InChI

InChI=1S/C9H10O4/c10-5-7-1-3-8(4-2-7)13-6-9(11)12/h1-4,10H,5-6H2,(H,11,12)

InChIKey

VUCNQOPCYRJCGQ-UHFFFAOYSA-N

SMILES

C(O)(=O)COC1=CC=C(CO)C=C1

CAS DataBase Reference

68858-21-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36/37/39-27-26

WGK Germany 

3

F 

10

HS Code 

29189900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-(Hydroxymethyl)phenoxyacetic acid Usage And Synthesis

Chemical Properties

Beige powder

Uses

4-(Hydroxymethyl)phenoxyacetic acid is a linkage agent used in solid-phase peptide synthesis according to the "FMOC-polyamide" technique.

reaction suitability

reagent type: linker

Synthesis

To a mixed solution of tetrahydrofuran ( 12 m L) and water ( 8 m L) of the precursor compound ester ( 312 mg , 1.48 mmol) was added lithium hydroxide ( 109 mg, 4.46 mmol) in aqueous solution, the resulting mixture was stirred and reacted at room temperature for 2 h. Then the tetrahydrofuran was removed under vacuum, and the residue obtained was acidified with 5N HCl acidified to make the reaction aqueous solution pH = 2 and extracted with EtOAc ( 3 ?? 20 m L ). ) was extracted, the combined organic layers were washed with brine, the organic layer was dried over sodium sulfate and then evaporated under vacuum to give 4-(hydroxymethyl)phenoxyacetic acid as a white solid in 89 % yield.

4-(Hydroxymethyl)phenoxyacetic acid(68858-21-9)Related Product Information

• Tris(hydroxymethyl)nitromethane
• Glycolic acid
• Ethyl methoxyacetate
• Methyl 2,2-dimethylphenylacetate
• Phenoxyacetic acid
• Diethoxymethyl acetate
• acetic acid, triethoxy-, ethyl ester
• 2-Hydroxyphenylacetic acid
• 4-Hydroxyphenylacetic acid
• 4-Methylphenylacetic acid
• Methoxyacetic acid
• 4-(Hydroxymethyl)benzoic acid
• Sodium methylparaben
• Methyl 4-cyanobenzoate
• Sodium propylparaben
• Ethyl 4-cyanobenzoate
• 4-CARBOXYPHENOXYACETIC ACID
• FENOFIBRIC ACID, HYDROXYMETHYL