2-Nitrobenzenesulfonyl chloride Chemical Properties

Melting point:

63-67 °C(lit.)

Boiling point:

350.6±25.0 °C(Predicted)

Density 

1.606±0.06 g/cm3(Predicted)

storage temp. 

Store below +30°C.

form 

powder to crystal

color 

White to Yellow to Orange

Water Solubility 

Soluble in toluene, tetrahydrofuran, methylene chloride, ethyl acetate and dimethylformamide. Insoluble in water.

Sensitive 

Moisture Sensitive

BRN 

521155

InChI

InChI=1S/C6H4ClNO4S/c7-13(11,12)6-4-2-1-3-5(6)8(9)10/h1-4H

InChIKey

WPHUUIODWRNJLO-UHFFFAOYSA-N

SMILES

C1(S(Cl)(=O)=O)=CC=CC=C1[N+]([O-])=O

CAS DataBase Reference

1694-92-4(CAS DataBase Reference)

EPA Substance Registry System

Benzenesulfonyl chloride, 2-nitro- (1694-92-4)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

21

Hazard Note 

Corrosive/Moisture Sensitive

TSCA 

TSCA listed

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

Storage Class

4.1A - Other explosive hazardous materials

Hazard Classifications

Eye Dam. 1
Skin Corr. 1B

MSDS

• Language:English Provider:2-Nitrobenzenesulfonyl chloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Nitrobenzenesulfonyl chloride Usage And Synthesis

Chemical Properties

Off-white tot yellow crystalline powder

Uses

2-Nitrobenzenesulfonyl chloride acts as a reagent to form 2-nitrobenzenesulfonyl derivatives of alcohols and amines. It is also involved in the selective cleavage with thiophenol without displacement of the nitro group. Further, it is used in the preparation of renin inhibitors. In addition to this, it finds application as an anticonvulsant.

Production Methods

2-Nitrobenzenesulfonyl chloride is isolated as an intermediate in the production of 2-nitrobenzenesulfonic acid. When 2,2' - dinitrodiphenyl disulfide is chlorinated in an organic solvent the product is 2-nitrophenylsulfenyl chloride.

Anticancer Research

2-Nitrobenzenesulfonyl chloride has also been shown to inhibit cancer cells as well as human serum through hydrogen bond interactions.

2-Nitrobenzenesulfonyl chloride(1694-92-4)Related Product Information

• Thionyl chloride
• Sodium chloride
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• 4-ISOPROPYLBENZENESULFONYL CHLORIDE
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