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Dideoxyadenosine

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Dideoxyadenosine Basic information

Product Name:
Dideoxyadenosine
Synonyms:
  • [(2S,5R)-5-(6-Aminopurin-9-yl)oxolan-2-yl]methanol
  • NSC 98700
  • Didanosine Related CoMpound B
  • 2',3'-DIDEOXYADENOSINE extapure
  • 2’,3’-dideoxy-adenosin
  • 2',3'-Dideoxy-D-adenosine
  • 9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine
  • Didanosine Impurity 7(Didanosine EP Impurity G)
CAS:
4097-22-7
MF:
C10H13N5O2
MW:
235.24
EINECS:
223-853-2
Product Categories:
  • Carbohydrates & Derivatives
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Isotope Labelled Compounds
  • Antivirals for Research and Experimental Use
  • Biochemistry
  • Chemical Reagents for Pharmacology Research
  • Nucleosides and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Bases & Related Reagents
Mol File:
4097-22-7.mol
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Dideoxyadenosine Chemical Properties

Melting point:
181-184 °C(lit.)
alpha 
D25 -25.2° (c = 1.01 in water)
Boiling point:
377.64°C (rough estimate)
Density 
1.2455 (rough estimate)
refractive index 
-34 ° (C=1, H2O)
storage temp. 
-20°C
solubility 
DMF: 1 mg/mL; DMSO: 2 mg/mL; Ethanol: Slightly soluble
pka
pKa 3.84(H2O t=25.0±0. I=0.01) (Uncertain)
form 
Powder
color 
White to Off-white
Water Solubility 
43.2g/L(25 ºC)
Merck 
14,3101
BRN 
619924
InChIKey
WVXRAFOPTSTNLL-NKWVEPMBSA-N
CAS DataBase Reference
4097-22-7(CAS DataBase Reference)
EPA Substance Registry System
Adenosine, 2',3'-dideoxy- (4097-22-7)
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Safety Information

Hazard Codes 
C
Risk Statements 
34-36/37-22
Safety Statements 
26-27-36/37/39-45-24/25
WGK Germany 
2
RTECS 
AU7358900
HS Code 
29349990
Toxicity
LD50 oral in mouse: 5gm/kg

MSDS

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Dideoxyadenosine Usage And Synthesis

Chemical Properties

Beige power

Uses

Dideoxy Adenosine (Didanosine EP Impurity G) is a potent anti-HIV agent.

Uses

2′,3′-Dideoxyadenosine (ddA), a specific adenylyl cyclase inhibitor, is useful in biological process and pathway studies involving adenylyl cyclase activity and cAMP pool modulation.

Uses

A potent labelled anti-HIV agent.

Uses

A potent anti-HIV agent.

Definition

ChEBI: A purine 2',3'-dideoxyribonucleoside in which the nucleobase component is specified as adenine.

General Description

Off-white powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Dideoxyadenosine may be sensitive to prolonged exposure to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to a related compound include cutaneous eruptions, fever, mouth sores, thrombocytopenia, neutropenia, reversible peripheral neuropathy, gastrointestinal distress, headache, nausea and vomiting.

Fire Hazard

Flash point data for Dideoxyadenosine are not available; however, Dideoxyadenosine is probably combustible.

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