Dideoxyadenosine Chemical Properties

Melting point:

181-184 °C(lit.)

alpha 

D25 -25.2° (c = 1.01 in water)

Boiling point:

377.64°C (rough estimate)

Density 

1.2455 (rough estimate)

refractive index 

-34 ° (C=1, H2O)

storage temp. 

-20°C

solubility 

DMF: 1 mg/mL; DMSO: 2 mg/mL; Ethanol: Slightly soluble

pka

pKa 3.84(H2O t=25.0±0. I=0.01) (Uncertain)

form 

Powder

color 

White to Off-white

Water Solubility 

43.2g/L(25 ºC)

Merck 

14,3101

BRN 

619924

InChIKey

WVXRAFOPTSTNLL-NKWVEPMBSA-N

CAS DataBase Reference

4097-22-7(CAS DataBase Reference)

EPA Substance Registry System

Adenosine, 2',3'-dideoxy- (4097-22-7)

Safety Information

Hazard Codes 

C

Risk Statements 

34-36/37-22

Safety Statements 

26-27-36/37/39-45-24/25

WGK Germany 

2

RTECS 

AU7358900

HS Code 

29349990

Toxicity

LD50 oral in mouse: 5gm/kg

MSDS

• Language:English Provider:2',3'-Dideoxy-adenosine
• Language:English Provider:SigmaAldrich

Dideoxyadenosine Usage And Synthesis

Chemical Properties

Beige power

Uses

Dideoxy Adenosine (Didanosine EP Impurity G) is a potent anti-HIV agent.

Uses

2′,3′-Dideoxyadenosine (ddA), a specific adenylyl cyclase inhibitor, is useful in biological process and pathway studies involving adenylyl cyclase activity and cAMP pool modulation.

Uses

A potent labelled anti-HIV agent.

Uses

A potent anti-HIV agent.

Definition

ChEBI: A purine 2',3'-dideoxyribonucleoside in which the nucleobase component is specified as adenine.

General Description

Off-white powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Dideoxyadenosine may be sensitive to prolonged exposure to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to a related compound include cutaneous eruptions, fever, mouth sores, thrombocytopenia, neutropenia, reversible peripheral neuropathy, gastrointestinal distress, headache, nausea and vomiting.

Fire Hazard

Flash point data for Dideoxyadenosine are not available; however, Dideoxyadenosine is probably combustible.

Dideoxyadenosine(4097-22-7)Related Product Information

• 2',3'-Dideoxyguanosine
• 2',3'-Dideoxythymidine
• EC 3.5.4.4
• 5'-Deoxyadenosylcobalamin
• 2'-Deoxyadenosine
• Adenosine
• Cyclic AMP
• Vidarabine
• ADENOSINE 5'-TRIPHOSPHATASE
• Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI)
• 2'-Deoxyadenosine monohydrate
• 2'-Deoxyadenosine 5'-phosphate
• DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS*
• 8-BROMOADENOSINE
• 5'-Tosyladenosine
• Adenosine 5'-monophosphate monohydrate
• 2-Chloroadenosine
• N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine