3-Acetylthio-2-methylpropanoic acid Chemical Properties

Melting point:

55-57°C

Boiling point:

276.5±23.0 °C(Predicted)

Density 

1.213±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Low-Melting Solid to Solid

pka

4.22±0.10(Predicted)

color 

White to Off-White

LogP

0.880 (est)

CAS DataBase Reference

33325-40-5(CAS DataBase Reference)

EPA Substance Registry System

3-(Acetylthio)-2-methylpropanoic acid (33325-40-5)

Safety Information

Hazard Codes 

Xi

HS Code 

2930909899

3-Acetylthio-2-methylpropanoic acid Usage And Synthesis

Chemical Properties

White Solid

Uses

3-Acetylthio-2-methylpropionic acid is a key intermediate for Captopril (C175750) and other hypertension drugs.

Purification Methods

Distil the acid under high vacuum and recrystallise it from *C6H6. [Fredga & Mastersson Chem Abstr 38 3616 1944.]

3-Acetylthio-2-methylpropanoic acid(33325-40-5)Related Product Information

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• N-ACETYL-L-TYROSINE ETHYL ESTER
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• 3-Mercaptopropionic acid
• 2,2-Bis(hydroxymethyl)propionic acid
• ISOOCTYL 3-MERCAPTOPROPIONATE
• Folic acid
• DL-Phenylalanine
• Acetylacetone
• Citric acid
• Isobutyric acid
• Mercaptoacetic acid
• POTASSIUM THIOGLYCOLATE
• ETHYL THIOGLYCOLATE
• Thiophanate-methyl
• Ethyl 2-(Chlorosulfonyl)acetate
• 2-Ethylhexyl mercaptoacetate
• Dimethyl sulfide