(1H-PYRAZOL-4-YL)METHANOL Chemical Properties

Boiling point:

326.8±17.0 °C(Predicted)

Density 

1.311±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in DMSO

pka

13.78±0.50(Predicted)

form 

Solid

color 

White to off-white

InChI

InChI=1S/C4H6N2O/c7-3-4-1-5-6-2-4/h1-2,7H,3H2,(H,5,6)

InChIKey

JRMKJOOJKCAEJK-UHFFFAOYSA-N

SMILES

N1C=C(CO)C=N1

Safety Information

HS Code 

2933199090

(1H-PYRAZOL-4-YL)METHANOL Usage And Synthesis

Uses

Callistephin (chloride) (Standard) is the analytical standard of Callistephin (chloride). This product is intended for research and analytical applications. Callistephin (Pelargonidin 3-O-glucoside) chloride is an anthocyanin that can be found in strawberries and chokeberries.

Definition

ChEBI: 4-Hydroxymethylpyrazole is a member of pyrazoles.

Synthesis

In a flame-dried round-bottom flask (RBF), a suspension of lithium aluminum hydride (LAH, 45.2 mL, 45.2 mmol, 1 M in tetrahydrofuran (THF)) was cooled to 0°C. Subsequently, a solution of ethyl 1H-pyrazole-4-carboxylate (3.17 g, 22.6 mmol) dissolved in THF (20 mL) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and stirred overnight at room temperature. Upon completion of the reaction, the mixture was cooled in an ice bath and 1.36 mL of water and 10 mL of 1 M sodium hydroxide (NaOH) solution were added sequentially dropwise to carefully quench the reaction, followed by stirring for 20 min. Solid magnesium sulfate (MgSO4) was added to dry the reaction mixture, and stirring was continued at room temperature for 30 min after removal of the ice bath. The solids were removed by filtration through diatomaceous earth (CELITE) and the filter cake was washed with THF and methanol (MeOH), respectively. The filtrates were combined and evaporated to give the target product (1H-pyrazol-4-yl) methanol (1.75 g, 78.9% yield) as a white solid. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 500 MHz, DMSO-d6): δ 12.58 (broad single peak, 1H), 7.58 (single peak, 1H), 7.40 (single peak, 1H), 4.74 (triple peak, J = 5.5 Hz, 1H), 4.37 (double peak, J = 5.2 Hz, 2H).

References

[1] Patent: WO2017/40449, 2017, A1. Location in patent: Paragraph 00176
[2] Patent: WO2011/121555, 2011, A1. Location in patent: Page/Page column 206
[3] Patent: US2013/96119, 2013, A1. Location in patent: Paragraph 1626; 1627
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 4000
[5] Patent: WO2006/74925, 2006, A1. Location in patent: Page/Page column 48

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