6-Hydroxy-1-tetralone Chemical Properties

Melting point:

154-157 °C(lit.)

Boiling point:

358.0±31.0 °C(Predicted)

Density 

1.236±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

8.22±0.20(Predicted)

form 

Crystalline Powder

color 

Off-white to brown

InChIKey

FNSQPQKPPGALFA-UHFFFAOYSA-N

CAS DataBase Reference

3470-50-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29145090

MSDS

• Language:English Provider:SigmaAldrich

6-Hydroxy-1-tetralone Usage And Synthesis

Chemical Properties

gray powder

Uses

6-Hydroxy-1-tetralone is used as a starting material for a one-pot conversion of phenols to anilines.

Uses

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) may be used in the synthesis of:

• 5-chloromethyl-6-hydroxy-3,4-dihydro-1(2H)-naphthalenone
• 6-(4-(3-(piperidin-1-yl)propoxy)benzyloxy)-1-tetralone
• 6-(3-(piperidin-1-yl)propoxy)-1-tetralone

Synthesis Reference(s)

Journal of Medicinal Chemistry, 41, p. 1068, 1998 DOI: 10.1021/jm970527v
Journal of the American Chemical Society, 99, p. 5810, 1977 DOI: 10.1021/ja00459a052

General Description

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) can be prepared by the demethylation of 6-methoxy-3,4-dihydro-1(2H)-naphthalenone. It participates in the synthesis of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. Its pKa value has been reported to be 7.74.

6-Hydroxy-1-tetralone(3470-50-6)Related Product Information

• 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
• 8-HYDROXY-2-TETRALONE
• 6,7-Dimethoxy-1-tetralone
• 6-Hydroxy-1-tetralone
• 6-methoxy-1-tetralone
• Ketazocine
• 4-Hydroxy-3,4-dihydronaphthalen-1(2H)-one
• 5-HYDROXY-1-TETRALONE,3,4-Dihydro-5-Hydroxyl-1(2H)-Naphthalen one 5-Hydroxy-1-Tetralone
• 7-HYDROXY-2-TETRALONE
• 7-HYDROXY-1-TETRALONE
• 5-HYDROXY-2-TETRALONE
• 6-Hydroxy-2-tetralone
• CHEMBRDG-BB 6368122
• 3,11-DIMETHOXY-7-PHENYL-6,8,9,13B-TETRAHYDRO-5H-DIBENZO[C,H]XANTHYLIUM PERCHLORATE
• dactylocycline B
• hatomarubigin A
• 6-METHOXY-2-METHYL-1-TETRALONE
• dactylocycline A