2-Amino-3-hydroxypyridine Chemical Properties

Melting point:

168-172 °C (lit.)

Boiling point:

206.4°C (rough estimate)

Density 

1.2111 (rough estimate)

vapor pressure 

0.007-0.28Pa at 20-50℃

refractive index 

1.4800 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

5.15±0.10(Predicted)

form 

Crystalline Powder

color 

Grayish-beige to brownish

BRN 

109868

InChIKey

BMTSZVZQNMNPCT-UHFFFAOYSA-N

LogP

-0.25 at 23℃ and pH7.02-7.04

Surface tension

72.6mN/m at 1.053g/L and 20℃

CAS DataBase Reference

16867-03-1(CAS DataBase Reference)

NIST Chemistry Reference

2-Amino-3-hydroxypyridine(16867-03-1)

Safety Information

Hazard Codes 

Xi,T,Xn

Risk Statements 

36/37/38-25-40

Safety Statements 

26-45-37/39-28A-36-22

RIDADR 

UN2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333999

MSDS

• Language:English Provider:2-Amino-3-pyridinol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-3-hydroxypyridine Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 14, p. 203, 1977 DOI: 10.1002/jhet.5570140206

General Description

2-Amino-3-hydroxypyridine forms complexes with number of transition metals. It inhibits the corrosion of aluminium and copper in acidic solutions. It undergoes condensation with 2-hydroxy-1-naphthaldehyde and 2-hydroxybenzaldehyde to form Schiffs bases. It is useful in the preparation of clinical anti-inflammatory analgesics.

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