PIRONETIN
PIRONETIN Basic information
- Product Name:
- PIRONETIN
- Synonyms:
-
- PIRONETIN
- 2H-Pyran-2-one, 5-ethyl-5,6-dihydro-6-[(2R,3S,4R,5S,7E)-2-hydroxy-4-methoxy-3,5-dimethyl-7-nonen-1-yl]-, (5R,6R)-
- CAS:
- 151519-02-7
- MF:
- C19H32O4
- MW:
- 324.45
- Product Categories:
-
- Antibiotic
- Mol File:
- 151519-02-7.mol
PIRONETIN Chemical Properties
- Melting point:
- 75-77 °C
- Boiling point:
- 473.1±40.0 °C(Predicted)
- Density
- 0.993±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble
- form
- A solid
- pka
- 14.28±0.20(Predicted)
- color
- Colorless to off-white
PIRONETIN Usage And Synthesis
Uses
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity[1][2].
Definition
ChEBI: Pironetin is an aliphatic alcohol.
in vivo
Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect[1].
| Animal Model: | Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells[1] |
| Dosage: | 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 5 days |
| Result: | Showed a moderate antitumor effect. |
References
[1] Kondoh M, et al. Cell cycle arrest and antitumor activity of pironetin and its derivatives. Cancer Lett. 1998 Apr 10;126(1):29-32. DOI:10.1016/s0304-3835(97)00528-4
[2] Yang J, et al. Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule. ] Nat Commun. 2016 Jun 30;7:12103. DOI:10.1038/ncomms12103
PIRONETINSupplier
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 15911056312
- liming@bio-fount.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- 18818260767
- sales@chemegen.com
- Tel
- 13348960310
- 3003867561@qq.com