Erlotinib D6 HCl Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: slightly, heated,Methanol: slightly soluble

form 

A solid

color 

White to off-white

Erlotinib D6 HCl Usage And Synthesis

Description

Erlotinib-d₆ (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC₅₀ = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED₅₀ value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC₅₀ = 4.6 μM) and JAK2 mutant JAK2^V617F (IC₅₀ = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.

Uses

Erlotinib D6 HCl is a Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, Antineoplastic.;Labeled Erlotinib, intended for use as an internal standard for the quantification of Erlotinib by GC- or LC-mass spectrometry.

Erlotinib D6 HCl(1189953-78-3)Related Product Information

• Axitinib
• OSI-420
• 4-Methyl Erlotinib Hydrochloride
• 2,3,5-Trimethylpyridine-1-Oxide
• Didesmethyl Erlotinib Hydrochloride Salt
• Erlotinib iMpurity B
• Icotinib Impurity 1
• Erlotinib
• Erlotinib Impurity 93
• Icotinib Impurity 5
• 2-ETHYNYLANILINE 98
• Erlotinib
• Erlotinib Imp.9
• Erlotinib hydrochloride
• Erlotinib Hydrochloride iMpurity
• 4-ETHYNYLANILINE
• DesMethyl Erlotinib Carboxylate Acid
• 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline