Bromoacetamido-PEG4-NHS ester CAS#: 1260139-70-5

Bromoacetamido-PEG4-NHS ester Basic information

Product Name:

Bromoacetamido-PEG4-NHS ester

Synonyms:

Bromoacetamido-PEG4-NHS ester
Bromoacetamido-PEG5-NHS ester
2,5-Dioxopyrrolidin-1-yl 1-bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
CAS_1260139-70-5
4,7,10,13-Tetraoxa-16-azaoctadecanoic acid, 18-bromo-17-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
BrCH2CONH-PEG4-NHS ester

CAS:

1260139-70-5

MF:

C17H27BrN2O9

MW:

483.31

Mol File:

1260139-70-5.mol

More

Less

Bromoacetamido-PEG4-NHS ester Chemical Properties

storage temp.: Storage temp. -20°C
form: Oil
color: Colorless to light yellow

More

Less

Safety Information

HS Code: 2942000090

More

Less

Bromoacetamido-PEG4-NHS ester Usage And Synthesis

Description

Bromoacetamido-PEG4-NHS ester is a PEG linker containing a bromide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromoacetamido-PEG4-NHS esterSupplier

Borenpharm Co., Ltd

Tel: 027-65563561
Email: sales@borenpharm.com

Amadis Chemical Company Limited

Tel: 571-89925085
Email: sales@amadischem.com

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Email: info@amateksci.com

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com

Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Email: 2853979817@qq.com

More

Less