Amino-PEG1-acid Chemical Properties

Boiling point:

284.7±20.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in Water, DMSO, DMF

form 

Solid

pka

4.17±0.10(Predicted)

color 

White

InChI

InChI=1S/C5H11NO3/c6-2-4-9-3-1-5(7)8/h1-4,6H2,(H,7,8)

InChIKey

ZCQVVSMJNBNDAQ-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCN

Safety Information

HS Code 

2942000090

Amino-PEG1-acid Usage And Synthesis

Description

Amino-PEG1-acid is a PEG linker containing an amino group (NH2) with a terminal carboxylic acid (CO2H). NH2 group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.

Uses

Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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