Bis-PEG5-PFP ester Chemical Properties

Boiling point:

606.0±55.0 °C(Predicted)

Density 

1.443±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

solid or viscous liquid

Bis-PEG5-PFP ester Usage And Synthesis

Description

Bis-PEG5-PFP ester is a PEG linker containing two PFP ester moieties. PFP esters are activated esters which react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

Bis-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

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