Bis-Propargyl-PEG10 Chemical Properties

Boiling point:

529.5±45.0 °C(Predicted)

Density 

1.076±0.06 g/cm3(Predicted)

Bis-Propargyl-PEG10 Usage And Synthesis

Description

Bis-propargyl-PEG10 is reactive with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry. By introducing PEG units into the molecule, the solubility of the compound in aqueous environment can be improved.

Uses

Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands[1]. Bis-propargyl-PEG9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Shan M, et al. Conformational analysis of bivalent estrogen receptor ligands: from intramolecular to intermolecular binding. Chembiochem. 2011 Nov 25;12(17):2587-98. DOI:10.1002/cbic.201100529

Bis-Propargyl-PEG10(1351373-47-1)Related Product Information

• Bis-propargyl-PEG10
• Bis-Propargyl-PEG9
• Bis-propargyl-PEG8
• Bis-Propargyl-PEG4
• Bis-propargyl-PEG6
• Diethylene Glycol Bis(2-propynyl) Ether
• DIPROPARGYL ETHER
• Bis-propargyl-PEG14
• Bis-Propargyl-PEG7
• Bis-propargyl-PEG11
• Bis-Propargyl-PEG13
• Bis-propargyl-PEG16