Bromo-PEG2-phosphonic acid CAS#: 1446282-44-5

Bromo-PEG2-phosphonic acid Basic information

Product Name:

Bromo-PEG2-phosphonic acid

Synonyms:

Bromo-PEG2-phosphonic acid
Phosphonic acid, P-[2-[2-(2-bromoethoxy)ethoxy]ethyl]-

CAS:

1446282-44-5

MF:

C6H14BrO5P

MW:

277.05

Mol File:

1446282-44-5.mol

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Bromo-PEG2-phosphonic acid Usage And Synthesis

Description

Bromo-PEG2-phosphonic acid is a PEG linker containing bromine and phosphonic acid moieties. The bromine group is a good leaving group and participates in substiution reactions. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.

Uses

Bromo-PEG2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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