Mal-Amido-PEG4-acid CAS#: 1263045-16-4

Mal-Amido-PEG4-acid Basic information

Product Name:

Mal-Amido-PEG4-acid

Synonyms:

Mal-CH2CH2CONH-PEG4-CH2CH2COOH
1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-oic acid
19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
Maleimide-NH-PEG4-CH2CH2COOH
Maleimide-PEG4-propionic acid
MAL-AMIDO-PEG4-COOH
Mal-NH-PEG4-COOH
Mal-Amido-PEG4-acid

CAS:

1263045-16-4

MF:

C18H28N2O9

MW:

416.42

Product Categories:

peg

Mol File:

1263045-16-4.mol

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Mal-Amido-PEG4-acid Chemical Properties

Boiling point:: 659.1±55.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, DMF, DCM
form: powder to crystal
pka: 4.28±0.10(Predicted)
color: White to Gray to Brown
CAS DataBase Reference: 1263045-16-4

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Safety Information

HS Code: 3822000000

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Mal-Amido-PEG4-acid Usage And Synthesis

Description

Mal-amido-PEG4-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

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