Methyltetrazine-PEG4-Acid CAS#: 1802907-91-0

Methyltetrazine-PEG4-Acid Basic information

Product Name:

Methyltetrazine-PEG4-Acid

Synonyms:

Methyltetrazine-PEG4-Acid
Methyltetrazine-PEG4-COOH
Methyltetrazine-PEG4-COOH,Methyltetrazine-PEG4-Acid
Propanoic acid, 3-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]-
3-(2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)propanoic acid
1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oic acid
Methyltetrazine-PEG4-Acid (CCT-1073)

CAS:

1802907-91-0

MF:

C20H28N4O7

MW:

436.46

Mol File:

1802907-91-0.mol

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Methyltetrazine-PEG4-Acid Chemical Properties

Boiling point:: 647.6±65.0 °C(Predicted)
Density: 1.236±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in Water, DMSO, DMF, DCM
pka: 4.28±0.10(Predicted)
form: Solid
color: Purple to purplish red

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Methyltetrazine-PEG4-Acid Usage And Synthesis

Description

Methyltetrazine-PEG4-Acid is a stable tetrazines molecule containing a terminal carboxylic acid (CO2H) The terminal acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. Methyltetrazine enable fast click chemistry with TCO ((trans-cycloctene), methyl group enhances the stability of tetrazine moiety.

Uses

Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methyltetrazine-PEG4-AcidSupplier

Borenpharm Co., Ltd

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BioPharmaMatrix,Inc.

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Jinan elephant international trading co., LTD

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Amatek Scientific Co. Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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