m-PEG2-acid Chemical Properties

Boiling point:

244.2±20.0 °C(Predicted)

Density 

1.098±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C6H12O4/c1-9-4-5-10-3-2-6(7)8/h2-5H2,1H3,(H,7,8)

InChIKey

KWMXBFIAGYXCCC-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCOC

m-PEG2-acid Usage And Synthesis

Description

m-PEG2-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Definition

ChEBI: 3-(2-methoxyethoxy)propanoic acid is a monocarboxylic acid that is propanoic acid substituted at C-3 by a 2-methoxyethoxy group. It has a role as a metabolite. It is a monocarboxylic acid and an ether.

IC 50

PEGs

References

[1] Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. DOI:10.3762/bjoc.11.74

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