PEG10-Tos
PEG10-Tos Basic information
- Product Name:
- PEG10-Tos
- Synonyms:
-
- PEG10-Tos
- Tos-PEG9-OH
- Peg10-ots
- Tos-PEG9
- 3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diol, 1-(4-methylbenzenesulfonate)
- OH-PEG9-Tos
- 26-Hydroxy-3,6,9,12,15,18,21,24-octaoxahexacosyl 4-methylbenzenesulfonate
- HO-(CH2CH2O)9-Tos
- CAS:
- 62573-11-9
- MF:
- C25H44O12S
- MW:
- 568.67
- Mol File:
- 62573-11-9.mol
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PEG10-Tos Chemical Properties
- storage temp.
- 2-8°C, sealed storage, away from moisture
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
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PEG10-Tos Usage And Synthesis
Description
PEG10-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tos-PEG9 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
PEG10-TosSupplier
Nanjing Junnahe Biopharmaceutical Co., Ltd
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- 025-58367986 17351780683
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Shanghai Raise Chemical Technology Co.,Ltd
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Jinan elephant international trading co., LTD
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Amatek Scientific Co. Ltd.
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Xi'an Confluore Biological Technology Co., Ltd.
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