t-Boc-Aminoxy-PEG2-alcohol Chemical Properties

Density 

1.108±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

14.36±0.10(Predicted)

form 

Viscous Liquid

color 

Colorless to light yellow

t-Boc-Aminoxy-PEG2-alcohol Usage And Synthesis

Description

t-Boc-Aminooxy-PEG2-alcohol is a Boc-protected aminooxy compound. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Boc-Aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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