t-Boc-N-amido-PEG1-acid Chemical Properties

Boiling point:

385.0±27.0 °C(Predicted)

Density 

1.127±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

4.29±0.10(Predicted)

form 

Solid

color 

White to off-white

t-Boc-N-amido-PEG1-acid Usage And Synthesis

Description

t-Boc-N-amido-PEG1-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].

Biological Activity

Boc-NH-PEG1-CH2CH2COOH is a cleavable ADC linker containing 1 unit PEG, and also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used for the synthesis of antibody-drug conjugates (ADC) and PROTACs .

target

IC 50

PEGs; Alkyl/ether; Cleavable Linker

References

[1] Alex Cortez, et al.Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.
[2] Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1.

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