Thiol-PEG6-t-butyl ester Chemical Properties

Boiling point:

488.8±45.0 °C(Predicted)

Density 

1.072±0.06 g/cm3(Predicted)

pka

9?+-.0.10(Predicted)

Thiol-PEG6-t-butyl ester Usage And Synthesis

Biological Activity

HS-PEG6-CH2CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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