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3-Acetyl-2,5-dichlorothiophene

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3-Acetyl-2,5-dichlorothiophene Basic information

Product Name:
3-Acetyl-2,5-dichlorothiophene
Synonyms:
  • AKOS 1010
  • 3-ACETYL-2,5-DICHLOROTHIOPHENE
  • 2,5-DICHLORO-3-THIENYL METHYL KETONE
  • 1-(2,5-DICHLORO-3-THIENYL)-1-ETHANONE
  • 1-(2,5-DICHLORO-3-THIENYL)ETHAN-1-ONE
  • 1-(2,5-Dichloro-3-thienyl)ethanone
  • 1-(2,5-Dichloro-thiophen-3-yl)-ethanone
  • Ethanone, 1-(2,5-dichloro-3-thienyl)-
CAS:
36157-40-1
MF:
C6H4Cl2OS
MW:
195.07
EINECS:
252-893-3
Product Categories:
  • Heterocycle-oher series
  • Heterocycles series
  • Sulphur Derivatives
  • Thiophene&Benzothiophene
  • Miscellaneous
Mol File:
36157-40-1.mol
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3-Acetyl-2,5-dichlorothiophene Chemical Properties

Melting point:
37-40 °C (lit.)
Boiling point:
120-122°C 4mm
Density 
1.4514 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
solid
color 
White to Yellow to Orange
BRN 
121288
CAS DataBase Reference
36157-40-1(CAS DataBase Reference)
NIST Chemistry Reference
2,5-Dichloro-3-thienyl methyl ketone(36157-40-1)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-36/37/39-22-36/37
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29349990

MSDS

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3-Acetyl-2,5-dichlorothiophene Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

3-Acetyl-2,5-dichlorothiophene may be used in the following syntheses:

  • substituted chalcones
  • AL-4623A and AL-4862 (brinzolamide), inhibitors of topical carbonic anhydrase
  • 2,5-dichlorothiophene-3-carboxylic acid, which is the starting reagent required for the synthesis of 2,5-dichloro-N-(substituted amino-carbonothioyl)thiophene-3-carboxamides and 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones

Definition

ChEBI: 1-(2,5-Dichloro-3-thienyl)ethan-1-one is an aromatic ketone.

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