Sacubitril Sodium Chemical Properties

Melting point:

163-165°C

storage temp. 

-20°C, Hygroscopic

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Sacubitril Sodium Usage And Synthesis

Description

Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.

Uses

Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Sacubitril Sodium (149690-05-1)Related Product Information

• LCZ696(valsartan + sacubitril) impurity 35
• [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)-
• LCZ696(valsartan + sacubitril) impurity 31
• [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)-
• LCZ696(valsartan + sacubitril) impurity 34
• 2S,4R-Sacubitril
• Sacubatrava valsartan sodium hydrate
• Sacubitril Impurity 43
• Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester
• Sacubitrilat-d5