Sacubitril Sodium
Sacubitril Sodium Basic information
- Product Name:
- Sacubitril Sodium
- Synonyms:
-
- Sacubitril Sodium Salt
- Sacubitril sodium
- Valsartan Sodium
- sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
- AHU-377 (Sacubitril free base)
- AHU-377 sodium salt
- Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
- Thacubatra sodium
- CAS:
- 149690-05-1
- MF:
- C24H28NNaO5
- MW:
- 433.47259
- Mol File:
- 149690-05-1.mol
Sacubitril Sodium Chemical Properties
- Melting point:
- 163-165°C
- storage temp.
- -20°C, Hygroscopic
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- RRTBVEJIZWGATF-OIRVNKSWNA-M
- SMILES
- [Na+].C([O-])(=O)CCC(N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O |&1:8,10,r|
Sacubitril Sodium Usage And Synthesis
Description
Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.
Uses
Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
in vivo
In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle)[1].
Sacubitril sodium (30 and 100 mg/kg, PO) produces a dose-dependent antihypertensive effect in Dahl-SS rats[1].
Sacubitril Sodium Supplier
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Sacubitril Sodium (149690-05-1)Related Product Information
- LCZ696(valsartan + sacubitril) impurity 35
- [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)-
- LCZ696(valsartan + sacubitril) impurity 31
- [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)-
- LCZ696(valsartan + sacubitril) impurity 34
- 2S,4R-Sacubitril
- Sacubatrava valsartan sodium hydrate
- Sacubitril Impurity 43
- Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester
- Sacubitrilat-d5