4-(Methylthio)benzaldehyde Chemical Properties

Melting point:

6 °C

Boiling point:

86-90 °C1 mm Hg(lit.)

Density 

1.144 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.646(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

Specific Gravity

1.144

color 

Clear yellow

Water Solubility 

Not miscible in water.

Sensitive 

Stench

BRN 

636158

InChIKey

QRVYABWJVXXOTN-UHFFFAOYSA-N

LogP

2.24 at 30℃

CAS DataBase Reference

3446-89-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 4-(methylthio)-(3446-89-7)

EPA Substance Registry System

Benzaldehyde, 4-(methylthio)- (3446-89-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-36-26-7/9

RIDADR 

UN 3334

WGK Germany 

3

F 

13

Hazard Note 

Irritant/Stench

TSCA 

Yes

HS Code 

29309070

MSDS

• Language:English Provider:4-(Methylthio)benzaldehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-(Methylthio)benzaldehyde Usage And Synthesis

Chemical Properties

clear yellow liquid

Uses

4-(Methylthio)benzaldehyde is a building block for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of sulfur-containing terpyridine ligands. It is the intermediate for the synthesis of a class of pyrrole derivatives showing analgesic/anti-inflammatory activity.

Synthesis Reference(s)

Synthetic Communications, 24, p. 2665, 1994 DOI: 10.1080/00397919408010580

Synthesis

In the standard synthetic method, diphenyl sulfoxide (2.2 g, 0.01 mol) is mixed with brominated silica (18.18 g, 40 mmol Br/g silica) in a nonprotonic solvent such as dichloromethane (2 mL) or carbon tetrachloride. The reaction was carried out at room temperature while atmospheric water needed to be removed for 5 min. Upon completion of the reaction, the product was separated by simple filtration, followed by evaporation of the solvent to give diphenyl sulfide in its pure state (yield 1.84 g, 99%).

References

[1] Synthetic Communications, 2007, vol. 37, # 22, p. 4079 - 4083
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 8, p. 2525 - 2526
[3] Tetrahedron Letters, 2009, vol. 50, # 49, p. 6872 - 6876
[4] Journal of Sulfur Chemistry, 2014, vol. 35, # 1, p. 7 - 13
[5] Journal of Sulfur Chemistry, 2017, vol. 38, # 6, p. 597 - 603

4-(Methylthio)benzaldehyde(3446-89-7)Related Product Information

• Mercaptoacetic acid
• p-Tolualdehyde
• 2-(Trifluoromethyl)benzaldehyde
• 3-Mercaptopropionic acid
• 3-Methoxybenzaldehyde
• 3-(Trifluoromethyl)benzaldehyde
• 2-Ethylhexyl mercaptoacetate
• 4-Hydroxybenzaldehyde
• 4-Dimethylaminobenzaldehyde
• o-Anisaldehyde
• ISOMETHIOZIN
• p-Anisaldehyde
• Benzaldehyde
• Calcium thioglycolate
• Anisonitrile
• 4-Methoxycinnamic acid
• 3,3,4,4-diphenylsulfonetetracarboxylicdianhydride
• 2-Mercaptoethanol