WEHI-345 (analog)
WEHI-345 (analog) Basic information
- Product Name:
- WEHI-345 (analog)
- Synonyms:
-
- WEHI-345 (analog)
- WEHI-345 analogue
- Reaxys ID: 22174618
- WEHI-345 alog
- 2-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-3-methyl-
- WEHI 345 analog,WEHI345 analog
- CAS:
- 1354825-62-9
- MF:
- C23H25N7O
- MW:
- 415.49
- Mol File:
- 1354825-62-9.mol
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WEHI-345 (analog) Chemical Properties
- Boiling point:
- 688.0±55.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 30 mg/mL (72.20 mM)
- form
- Solid
- pka
- 12.67±0.46(Predicted)
- color
- White to gray
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WEHI-345 (analog) Usage And Synthesis
Uses
WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation[1].
IC 50
RIPK2
References
[1] Nachbur U, et al. A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17;6:6442. DOI:10.1038/ncomms7442
WEHI-345 (analog)Supplier
Amadis Chemical Company Limited
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- 571-89925085
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Musechem
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TargetMol Chemicals Inc.
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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- 18818260767
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Shanghai Zeye Biotechnology Co., Ltd.
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- 021-021-61998551 13122364865
- sale1@shzysw.net