ML264
ML264 Basic information
- Product Name:
- ML264
- Synonyms:
-
- ML264
- (2E)-3-(3-Chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-2-propenamide
- CID-51003603
- ML-264; ML264; ML 264; CID-51003603
- CS-2175
- 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-, (2E)-
- ML264 >=98% (HPLC)
- (E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(methyl)amino)-2-oxoethyl)acrylamide
- CAS:
- 1550008-55-3
- MF:
- C17H21ClN2O4S
- MW:
- 384.88
- Mol File:
- 1550008-55-3.mol
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ML264 Chemical Properties
- Boiling point:
- 701.0±60.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:64.0(Max Conc. mg/mL);166.63(Max Conc. mM)
- form
- A crystalline solid
- pka
- 12.84±0.46(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 1550008-55-3
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ML264 Usage And Synthesis
Uses
ML264 is a inhibitor of Krüppel-like Factor Five (KLF5).
in vivo
Single daily injections of ML264 at 10 mg/kg do not significantly affect tumor growth. However, twice daily injections of ML264 at 10 mg/kg or 25 mg/kg result in significant reductions in tumor growth, and this effect can be detected as early as two days after the first injection. The data also show that there is a concentration-dependent effect of ML264 on the tumor volume. Statistical analysis of tumor growth reveals significant tumor size reduction in mice treated twice daily with ML264 compared to those receiving only vehicle at day 5 and 10[2].
ML264Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com
Guangzhou Zhiya Chemdrugs Co.,Ltd
- Tel
- 18122150900
- sculk28@163.com
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