Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Basic information
- Product Name:
- Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
- Synonyms:
-
- ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE
- ETHYL 6,7,8-TRIFLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLATE
- 1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylicaciethylester
- dm-7
- ethyl1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylate
- CycliccompoundofLomefloxacin
- 6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester
- 3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline
- CAS:
- 79660-46-1
- MF:
- C12H8F3NO3
- MW:
- 271.19
- Product Categories:
-
- Building Blocks
- C11 to C30
- Chemical Synthesis
- Heterocyclic Building Blocks
- Quinolines
- Mol File:
- 79660-46-1.mol
Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Chemical Properties
- Melting point:
- 275 °C (dec.) (lit.)
- Boiling point:
- 344.3±42.0 °C(Predicted)
- Density
- 1.451
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.92±0.70(Predicted)
- Appearance
- Off-white to light brown Solid
- CAS DataBase Reference
- 79660-46-1(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Usage And Synthesis
Chemical Properties
beige to beige-brown powder
General Description
Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate is also referred to as 3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline.
Synthesis
100501-60-8
79660-46-1
General procedure for the synthesis of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate from diethyl 2-[[(2,3,4-trifluorophenyl)amino]methylene]malonate: Compound 2 (5.30 g, 16.70 mmol) was dissolved in diphenyl ether (35 mL), and the reaction was carried out at reflux for 8 hr at 250 °C. After completion of the reaction, the reaction mixture was cooled and the precipitate precipitated was collected by filtration. The precipitate was washed with hexane and subsequently recrystallized with ethanol to give the target product 3 as a white solid.
References
[1] Synthetic Communications, 2009, vol. 39, # 24, p. 4375 - 4383
[2] Tetrahedron, 2007, vol. 63, # 9, p. 2093 - 2097
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 4, p. 1232 - 1244
[4] Tetrahedron, 1992, vol. 48, # 29, p. 6135 - 6150
[5] Magnetic Resonance in Chemistry, 1996, vol. 34, # 11, p. 972 - 978
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Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate(79660-46-1)Related Product Information
- 3-Quinolinecarboxylic acid
- Ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
- 1-CYCLOPROPYL-5-AMIDO-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3- QUINOLINECARBOXYLIC ACID ETHYL ESTER
- ETHYL 1-CYCLOPROPYL-5,6,7,8-TETRAFLUORO-4(1H)-OXOQUINOLINE-3-CARBOXYLATE
- Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
- 1-CYCLOPROPYL-5-NITRO-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3- QUINOLINECARBOXYLIC ACID ETHYL ESTER