Fenfluramine hydrochloride Chemical Properties

Melting point:

1660C

Boiling point:

108-112 °C(Press: 12 Torr)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)

form 

A solid

Stability:

Hygroscopic

CAS DataBase Reference

404-82-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25-23/24/25

Safety Statements 

7-16-36/37-45-36/37/39-22

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

DA0295500

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 oral in rabbit: 50mg/kg

MSDS

• Language:English Provider:SigmaAldrich

Fenfluramine hydrochloride Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

Controlled substance. Anorexic

Definition

ChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

brand name

Pondimin (Robins).

General Description

Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT_1B and the 5-HT_2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl

Fenfluramine hydrochloride(404-82-0)Related Product Information

• 2-Phenylethylamine hydrochloride
• 1-AdaMantanethylaMine
• Ethyl acetate
• Topotecan hydrochloride
• 2-Ethylphenylhydrazine hydrochloride
• 2-Butanone oxime
• Propane
• Methyl 2-hydroxyethyl cellulose
• L-1-Phenylethylamine
• PHENYL VALERATE
• ISOXADIFEN-ETHYL
• Bis(2-ethylhexyl)amine
• Ethanol
• Ethylparaben
• Ethyl acrylate
• PHENYL RESIN
• FENFLURAMINE
• (+)-fenfluramine hydrochloride--dea*schedule iv I,(+)-FENFLURAMINE HYDROCHLORIDE